- Austria Wien 1-3 Rijeka (Kevin Friesenbichler 90'; Mario Gavranovic 21', 31', Zoran Kvrzic 92')
- AC Milan 0-0 AEK
Grup E
- Everton 1-2 Lyon (Ashley Williams 69'; Nabil Fekir 6'-penalti, Bertrand Traore 75')
- Atalanta 3-1 Apollon (Josip Ilicic 12', Andrea Petagna 64', Remo Freuler 66'; Andre Schembri 59')
Grup F
- Zlin 1-1 Kobenhavn (Dame Diop 11'; Peter Ankersen 19')
- Sheriff 1-1 Lokomotiv Moskva (Ziguy Badibanga 31'; Anton Miranchuk 17')
Grup G
- Lugano 3-2 Plzen (Mattia Bottani 63', Carlinhos 69', Alex Gerndt 88'; Michael Krmencik 76', Marek Bakos 90')
- Hapoel Beer Sheva 1-2 Steaua (Isaac Cuenca 87'; Harlem-Eddy Gnohere 70', 75')
Grup H
- Crvena Zvezda 0-1 Arsenal (Olivier Giroud 85')
- BATE 1-0 Koeln (Aleksey Rios 55')
Grup I
- Konyaspor 0-2 Salzburg (Fredrik Gulbrandsen 5', Mounas Dabbur 80')
- Marseille 2-1 Vitoria (Lucas Ocampos 28', Maxime Lopez 76'; Rafael 17')
Grup J
- Ostersund 2-2 Bilbao (Alhaji Gero 52', Curtis Edwards 64'; Aritz Aduriz 14', Inaki Williams 89')
- Zorya 2-1 Hertha Berlin (Silas 42', Oleksandr Svatok 79'; Davie Selke 56')
Grup K
- Zulte 1-1 Vitesse (Guram Kashia 23'-bunuh diri; Thomas Bruns 27')
- OGC Nice 1-3 Lazio (Mario Balotelli 4'; Felipe Caicedo 5', Sergej Milinkovic-Savic 65', 89')
Grup L
- Vardar 0-6 Sociedad (Mikel Oryazabal 12, Willian Jose 34', 42', 55', 59', Alberto de la Bella 90')
- Zenit St Petersburg 3-1 Rosenborg (Emiliano Rigoni 1', 68', 75'; Pal Helland 88')