- Dinamo Zagreb 4 - 1 Fenerbahce (Sunjić 16', Hajrović 27', 57', Olmo 60'; Neustadter 47')
- Spartak Trnava 1 - 0 Anderlecht (Oravec 79')
Grup E
- Arsenal 4 - 2 Vorskla (Aubameyang 32', 56', Welbeck 48, Oezil 74'; Chesnakov 76, Sharpar 90'+4)
- Sporting CP 2 - 0 Qarabag FK (Raphindha 54', Cabral 88')
Grup F
- F91 Dudelange 0 - 1 AC Milan (Higuain 59')
- Olympiacos 0 - 0 Real Betis (Tsimikas 73'-k.merah)
Grup G
- Rapid Wien 2 - 0 Spartak Moskva (Timofeev 50'-bunuh diri, Murg 68')
- Villarreal 2 - 2 Rangers FC (Bacca 1', Moreno 69'; Arfield 67', Lafferty 76')
Grup H
- Lazio 2 - 1 Apollon Limassol (Alberto 14', Immobile (PG) 84'; Zelaya 87')
- Marseille 1 - 2 Eintracht Frankfurt (Ocampos 3'; Lucas Torro 52', Jovic 89', Willems 59'-k.merah)
Grup I
- Besiktas 3 - 1 Sarpsborg 08 (Babel 51', Roco 69', Lens 82'; Zachariassen 90')
- Genk 2 - 0 Malmoe FF (Trossard 37, Samatta 71')
Grup J
- Akhisarspor 0 - 1 FC Krasnodar (Claesson 26')
- Sevilla 5 - 1 Standard Liege (Banega 8',74'-penalti, Vazquez 41', Ben Yedder 49',70'; Djenepo 39')
Grup K
- Dynamo Kyiv 2 - 2 FC Astana (Tsygankov 11', Harmash 45';Anicic 21', Murtazayev 90')
- Rennes 2 - 1 Jablonec (Sarr 31', Ben Arfa 90'-penalti; Travnik 54')
Grup L
- PAOK Thessaloniki FC 0 - 1 Chelsea (Willian 7')
- Vidi FC 0 - 2 BATE Borisov (Tuominen 27', Filipenko 85', Filipovic 90'-k.merah)