- Qarabag 0 - 3 Arsenal (Sokratis Papastathopoulos 4', Emile Smith Rowe 53' Matteo Guendouzi 79')
- Vorskla 1 - 2 Sporting CP (Vladyslav Kulach 10'; Fredy Montero 90', Jovana Cabral 90')
Grup F
- AC Milan 3 - 1 Olympiacos (Patrick Cutrone 70', 79', Gonzalo Higuain 76'; Miguel Angel Guerrero 14')
- Real Betis 3 - 0 F91 Dudelange (Antonio Sanabria 56', Giovani Lo Celso 80', Cristian Tello 88')
Grup G
- Rangers 3 - 1 Rapid Wien (Alfredo Morelos 44', 90', James Tavernier 84'; Veton Berisha 42')
- Spartak Moscow 3 - 3 Villarreal (Ze Luis Pen 34', 82', Lorenzo Melgarejo 85'; Karl Toko Ekambi 13'. Pablo Fornals 49', Santi Cazorla Pen 90')
Grup H
- Apollon Limassol 2 - 2 Marseille (Sasa Markovic 74', Emilio Jose Zelaya 90'; Dimitri Payet 50', Luiz Gustavo 67')
- Eintracht Frankfurt 4 - 1 Lazio (Danny da Costa 4', 90', Filip Kostic 28', Luka Jovic 52'; Marco Parolo 23')
Grup I
- Malmoe FF 2 - 0 Besiktas (Caner Erkin OG 53', Markus Rosenberg Pen 76')
- Sarpsborg 08 3 - 1 Genk (Patrick Mortensen 5', 63', Kristoffer Zachariassen 54'; Leandro Trossard 49')
Grup J
- FC Krasnodar 2 - 1 Sevilla (Mauricio Pereira 72', Tornike Okriashvili 88'; Charles Kabore OG 43')
- Standard Liege 2 - 1 Akhisarspor (Renaud Emond 17', Moussa Djenepo 40'; Onur Ayik 32')
Grup K
- FC Astana 2 - 0 Rennes (Baktiyor Zaynutdinov 64', Marin Tomasov 90')
- Jablonec 2 - 2 Dynamo Kyiv (David Hovorka 33', Michal Travnik81'; Viktor Tsigankov 8', Denis Garmash 14')
Grup L
- BATE Borisov 1 - 4 PAOK Thessaloniki FC (Jose Angel Crespo og 61'; Aleksandar Prijovic 6', Leo Jaba 11', 17', Dimitrios Pelkas 73')
- Chelsea 1 - 0 Vidi FC (Alvaro Morata 70')