- Real Betis 1 - 1 AC Milan (Giovani Lo Celso 12'; Suso 62')
- Olympiakos Piraeus 5 - 1 F91 Dudelange (Vassilis Torosidis 6', Konstantinos Fortounis 15', 36', Lazaros Christodoulopoulos 26', Koka 70'; Danel Sinani 69')
Grup G
- Rapid Wien 0 - 0 Villarreal
- Spartak Moskva 4 - 3 Rangers FC (Lorenzo Melgarejo 22', Connor Goldson 35'-bd, Luiz Adriano 58', Soufiane Hanni 59'; Roman Eremenko 5'-bd, Daniel Candeias 27', Glenn Middleton 41')
Grup H
- Apollon Limassol 2 - 3 Eintracht Frankfurt (Emilio Zelaya 71', 90'-pen; Luka Jovic 17', Sebastien Haller 55', Mijat Gacinovic 58')
- Lazio 2 - 1 Olympique Marseille (Marco Parolo 45', Joaquin Correa 55'; Florian Thauvin 60')
Grup I
- Genk 1 - 1 Besiktas (Sander Berge 87'; Ricardo Quaresma 16')
- Malmo FF 1 - 1 Sarpsborg (Marcus Antonsson 67'; Patrick Mortensen 63')
Grup J
- Krasnodar 2 - 1 Standard Liege (Magomed Suleymanov 79', Wamberto 82'; Mehdi Carcela 19')
- Akhisarspor 2 - 3 Sevilla (Elvis Manu 52', Onur Ayik 78'; Nolito 12', Luis Muriel 38', Ever Banega 87'-pen)
Grup K
- Astana 2 - 1 Jablonec (Pedro Henrique 18', Evgeny Postnikov 88'; Baktiyor Zainutdinov 40'-bd)
- Dynamo Kyiv 3 - 1 Rennes (Benjamin Verbic 13', Vitaly Mykolenko 68', Mykola Shaparenko 72'; Theoson Siebatcheu 89')
Grup L
- BATE Borisov 0 - 1 Chelsea (Olivier Giroud 52')
- Vidi 1 - 0 PAOK FC (Georgi Milanov 50')