- Qarabag 2-2 APOEL Nicosia (Dani Quintana 13', Aillton 58'; Maksim Medvedev 29'-bd, Linus Hallenius 45')
- Sevilla 3-0 F91 Dudelange (Franco Vazquez 48', 75', Munir El Haddadi 78';-)
Grup B
- Dynamo Kyiv 1-1 FC Copenhagen (Artem Shabanov 53'; Pieros Sotiriou 2')
- Malmoe FF 2-1 Lugano (Jo Inge Berget 13'-pen, Guillermo Molins 32'; Alexander Gerndt 50')
Grup C
- Getafe 0-1 FC Basel (-; Fabian Frei 18')
- Trabzonspor 0-2 FC Krasnodar (-; Marcus Berg 49', Tonny Vilhena 90')
Grup D
- PSV Eindhoven 0-0 LASK
- Sporting CP 1-0 Rosenborg (Yannick Bolasie 70';-)
Grup E
- Celtic 2-1 Lazio (Ryan Christie 67', Christopher Jullien 89'; Manuel Lazzari 40')
- Rennes 0-1 CFR Cluj (-; Ciprian Ioan Deac 9')
Grup F
- Arsenal 3-2 Vitoria Guimaraes (Gabriel Martinelli 32', Nicolas Pepe 80', 90'+2; Marcus Edewards 8', Bruno Duarte 36')
- Eintracht Frankfurt 2 - 1 Standard Liege (David Abraham 28', Martin Hinteregger 73'; Selim Amallah 82')
Grup G
- FC Porto 1-1 Rangers (Luis Diaz 36'; Alfredo Morelos 44')
- Youngs Boys 2-0 Feyenoord ( Roger Assale 14'-pen, Jean Pierre Nsame 28'-pen; -)
Grup H
- CSKA Moskow 0-1 Ferencvaros (-; Roland Varga 86')
- Ludogorets Razgrad 0 - 1 RCD Espanyol (-; Victor Campuzano)
Grup I
- Gent 2-2 Wolfsburg (Roman Yaremchuk 41', 90'; Wout Weghorst 3', Joao Victor 24')
- Saint-Etienne 1 - 1 Oleksandriya (Gabriel Silva 8' ; Gabriel Silva 14'-bd)
Grup J
- Istanbul Basaksehir 1 - 0 Wolfsberger AC (Irfan Kahveci 78' ; -)
- AS Roma 1-1 Borussia Moenchenggladbach (Nicolo Zaniolo 35' ; Lars Stindl 90'-pen)
Grup K
- Besiktas 1 - 2 SC Braga (Mehmet Umut Nayir 71' ; Ricardo Horta 38', Wilson Eduardo 80')
- Slovan Bratislava 1 - 2 Wolverhampton Wanderers (Anraz Sporar; Romain Saiss 58', Raul Jimenez 64')
Grup L
- AZ Alkmaar 6 - 0 FC Astana (Teun Koopmeiners 39', 83', Myron Boadu 43', Calvin Stengs 77', Yukinari Sugawara 85', Oussama Idrissi 90'+2)
- Partizan Beograd 0-1 Manchester United (Anthony Martial 43'-pen)