Grup A
- AS Roma 5-0 CFR Cluj (Henrikh Mkhitaryan 2', Roger Ibanez 23', Borja Mayoral 34', 83', Pedro Rodriguez 89')
- Young Boys 3-0 CSKA Sofia (Felix Mambimbi 3', 32', Miralem Sulejmani 18')
Grup B
- Rapid Wien 4-3 Dundalk (Dejan Ljubicic 22', Kelvin Arase 79', Maximilian Hofmann 87', Yusuf Demir 90+1'; Patrick Hoban 7', David McMillan 82'-pen, 90+2'-pen)
- Arsenal 4-1 Molde (Kristoffer Haugen 45'-bd, Sheriff Sinyan 62', Nicolas Pepe 70', Joseph Willock 88'; Martin Ellingsen 22')
Grup C
- Hapoel Beer Sheva 2-4 Bayer Leverkusen (Elton Acolatse 12', 25'; Leon Bailey 5', 75', Or Dadya 39'-bd, Florian Wirtz 88')
- Slavia Prague 3-2 Nice (Jan Kuchta 16', 71', Abdallah Sima 43'; Amine Gouiri 33', Dan Ndoye 90')
Grup D
- Benfica 3-3 Rangers (Connor Goldson 2'-bd, Rafa Silva 77', Darwin Nunez 90+1'; Diogo Goncalves 24'-bd, Glen Kamara 25', Alfredo Morelos 51')
- Lech Poznan 3-1 Standard Liege (Michal Skoras 14', Mikael Ishak 22', 48'; Maxime Lestienne 29')
Grup E
- Omonia Nicosia 0-2 Granada (Yangel Herrera 4', Luis Suarez 63')
- PAOK Athens 4-1 PSV Eindhoven (Stefan Schwab 47', Andrija Zivkovic 56', 67', Christos Tzolis 58'; Eran Zahavi 21'-pen)
Grup F
- Real Sociedad 1-0 AZ Alkmaar (Cristian Portu 58')
- Rijeka 1-2 Napoli (Robert Muric 13'; Diego Demme 43', Filip Braut 62'-bd, )
Grup G
- Leicester City 4-0 SC Braga (Kelechi Iheanacho 21', 48', Dennis Praet 67', James Maddison 78')
- Zorya 1-4 AEK Athens (Vladyslav Kochergin 81'; Muamer Tankovic 6', Petros Mantalos 34', Markos Livaja 53', 81')
Grup H
- AC Milan 0-3 Lille (Yusuf Yazici 22'-pen, 55', 58')
- Celtic 1-4 Sparta Prague (Leigh Griffiths 65'; Lukas Julis 26', 45', 77', Ladislav Krejci 90')
Grup I
- Sivasspor 2-0 Qarabag FK (Caner Osmanpasa 11', Olarenwaju Kayode 88')
- Villarreal 4-0 Maccabi Tel Aviv (Carlos Bacca 4', 52', Alejandro Baena 71', Fer Nino 81')
Grup J
- Ludogorets Razgard 1-3 Tottenham Hotspur (Claudiu Keseru 50'; Harry Kane 13', Lucas Moura 33', Giovani Lo Celso 62')
- Royal Antwerp 0-1 LASK (Johannes Eggestein 55')
Grup K
- Dinamo Zagreb 1-0 Wolsberger AC (Iyayi Believe Atiemwen 76')
- Feyenoord 3-1 CSKA Moskva (Ridgeciano Haps 63', Orkun Kokcu 71', Lutsharel Geertruida 72'; Marcos Senesi 80'-bd)
Grup L
- Crvena Zvezda 2-1 Gent (Guelor Kanga 13', Alesandar Katai 59'; Vadis Odjidja-Ofoe 31')
- Hoffenheim 5-0 Slovan Liberec (Munas Dabbur 22', 30', Florian Grillitsch 59', Sargis Adamyan 71', 76')