Sabtu (24/4/2021)
- Genoa 2-0 Spezia (Gianluca Scamacca 62', Eldor Shomurodov 86')
- Parma 3-4 Crotone (Hernani 29', Gervinho 49', Valentin Mihaila 54'; Lisandro Magallan 14', Simy 42', 69'-pen, Adam Ounas 45+1')
Minggu (25/4/2021)
- Sassuolo 1-0 Sampdoria (Domenico Berardi 69')
- Benevento 2-4 Udinese (Nicolas Viola 34'-pen, Gianluca Lapadula 83'; Nahuel Molina 4', Tolgay Arslan 31', Jens Styger Larsen 49', Jayden Braaf 73')
- Fiorentina 1-1 Juventus (Dusan Vlahovic 29'pen; Alvaro Morata 46')
- Inter Milan 1-0 Hellas Verona (Matteo Darmian 76')
- Cagliari 3-2 AS Roma (Charalambos Lykogiannis 4', Razvan Marin 57', Joao Pedro 64'; Carles Perez 27', Federico Fazio 69')
Senin (26/4/2021)
- Atalanta 5-0 Bologna (Ruslan Malinovsky 22', Luis Muriel 44', Remo Freuler 57', Duvan Zapata 59', Aleksey Miranchuk 73')
- Torino 0-2 Napoli (Tiemoue Bakayoko 11', Victor Osimhen 13')
- Lazio 3-0 AC Milan (Joaquin Correa 2', 51' Ciro Immobile 87')