Berikut ini hasil lengkap dan klasemen Liga Inggris 2021-2022 usai laga pekan keempat, Senin (13/9/2021):
- Crystal Palace 3-0 Tottenham Hotspur (Wilfried Zaha 76'-pen, Odsonne Edouard 84', 90+3')
- Arsenal 1-0 Norwich City (Pierre-Emerick Aubameyang 66')
- Brentford 0-1 Brighton & Hove Albion (Leandro Trossard 90')
- Leicester City 0-1 Manchester City (Bernardo Silva 62')
- Manchester United 4-1 Newcastle United (Cristiano Ronaldo 45+2', 62', Bruno Fernandes 80', Jesse Lingard 90+2'; Javier Manquillo 56')
- Southampton 0-0 West Ham United
- Watford 0-2 Wolverhampton Wanderers (Francisco Sierralta 74'-bd, Hwang Hee-Chan 83')
- Chelsea 3-0 Aston Villa (Romelu Lukaku 15', 90+3', Mateo Kovacic 49')
- Leeds United 0-3 Liverpool (Mohamed Salah 20', Fabinho 50', Sadio Mane 90+2')
- Everton 3-1 Burnley (Michael Keane 60', Andros Townsend 65', Demarai Gray 66'; Ben Mee 53')