- Olympique Lyon 3-0 Broendby (K.T. Ekambi 71', H.Aouar 86')
- Sparta Prague 1-0 Rangers (D.Hancko 29')
- Real Sociedad 1-1 AS Monaco (M. Merino 53'; A. Disasi 16')
- Sturn Graz 1-4 PSV Eindhoven
- Legia Warszawa 1-0 Leicester City (Mahir Emreli 31')
- Napoli 2-3 Spartak Moskow (Elif Elmas 1', Victor Osimhen 90+4';Quincy Promes 55', 90' Mikhail Ignatov 80').
- Fenerbahce 0-3 Olympiacos
- Royal Antwerp 0-1 Eintracht Frankfurt
- Celtic 0-4 Bayer Leverkusen (Piero Hincapie 25, Florian Wirtz 35', Lucas Alario 58'-pen, Amine Adli 90+4')
- West Ham 2-0 Rapid Wien (Declan Rice 29', Said Benrahma 90+4')
- Genk 0-3 Dinamo Zagreb (Luka Ivanusec 10', Bruno Petkovic 45+3', 67'=pen)
- Lazio 2-0 Lokomotiv Moskow (Toma Basic 13', Patric 38')
- Marseille 0-0 Galatasaray
- Ludogorets 0-1 Crvena Zvezda (Guelor Kanga 64')
- Ferencvaros 1-3 Real Betis (Mrto Uzuni 44'; Nabil Fekir 17', Henry Wingo 75'-Bd, Cristian Tello 90+5')
- Braga 3-1 Midtjylland (Galeno 55-pen, 90+5', Ricardo Horta 62'; Evander 19')