Berikut hasil dan klasemen Liga Italia 2021-2022 pada Minggu (21/11/2021) malam WIB hingga Senin (22/11/2021) dini hari WIB.
- Sassuolo 2-2 Cagliari (Gianluca Scamacca 37', Domenico Berardi 51'-pen; Keita Balde Diao 40', Joao Pedro 56'-pen)
- Bologna 0-1 Venezia (David Okereke 61')
- Salernitana 0-2 Sampdoria (Francesco Di Tacchio 40'-bd, Antonio Candreva 43')
- Inter Milan 3-2 Napoli (Hakan Calhanoglu 25'-pen, Ivan Perisic 44', Lautaro Martinez 61'; Piotr Zielinski 17', Dries Mertens 78')
- Genoa 0-2 AS Roma (Felix Afena-Gyan 82', 90+4')