Grup C
- AS Roma 3-0 HJK Helsinki (Paulo Dybala 47', Lorenzo Pellegrini 49', Andrea Belotti 68')
- Real Betis 3-2 Ludogorets (Luiz Henrique 25', Joaquin 39', Sergio Canales 59'; Kiril Despodov 45+1', Rick 74')
Grup D
- SC Braga 1-0 Union Berlin (Vitor Oliveira 77')
- St Gilloise 3-2 Malmo (Christian Burgess 17', Teddy Teuma 69', Victor Boniface 71'; Joseph Ceesay 6', Isaac Kiese Thelin 57')
Grup E
- Sheriff Tiraspol 0-2 Manchester United (Jadon Sancho 17', Cristiano Ronaldo 39'-pen)
- Real Sociedad 2-1 Omonia Nicosia (Ander Guevara 30', Alexander Sorloth 80'; Bruno 72')
Grup F
- Feyenoord 6-0 Sturm Graz (Alireza Jahanbakhsh 8', 41', David Hancko 31', Danilo Pereira 34', Santiago Gimenez 66', Oussama Idrissi 78')
- FC Midtjylland 5-1 Lazio (Paulinho 26', Sory Kaba 30', Evander 52'-pen, Gustav Isaksen 67', Erik Sviatchenko 72'; Sergej Milinkovic-Savic 57')
Grup G
- Qarabag 3-0 Nantes (Kwabwena Owusu 60', Abdellah Zoubir 65', Marko Jankovic 72')
- Olympiakos 0-3 Freiburg (Nicolas Hoefler 5', Michael Gregoritsch 25', 52')
Grup H
- AS Monaco 0-1 Ferencvaros (Balint Vecsei 80')
- Trabzonspor 2-1 Crvena Zvezda (Marek Hamsik 16', Trezeguet 68'; Veljko Nikolic 89')