- AS Roma 1-2 Real Betis (Paulo Dybala 34'-pen; Guido Rodriguez 40', Luis Henrique 88')
- HJK Helsinki 1-1 Ludogorets (Perparim Hetemaj 55'; Matias Tissera 10')
Grup D
- Malmo FF 0-1 FC Union Berlin (Sheraldo Becker 68')
- Braga 1-2 Union Saint-Gilloise (Abel Ruiz 49'; Gustaf Nilsson 86', 90+4')
Grup E
- Omonia 2-3 Manchester United (Karim Ansarifard 34', Nikolas Panayiotou 85'; Marcus Rashford 53', 84', Anthony Martial 63')
- Sheriff Tiraspol 0-2 Real Sociedad (David Silva 53', Aritz Elustondo 62')
Grup F
- Sturm Graz 0-0 Lazio
- FC Midtjylland 2-2 Feyenoord (Gustav Isaksen 54', Jose Carlos Ferreira Junior 85'; Sebastian Szymanski 21',Orkun Kokcu 45'-pen)
Grup G
- Olympiakos FC 0-3 Qarabag FK (Owusu Kwabena 68', Marko Vesovic 82', Ramil Sheydaev 86')
- SC Freiburg 2-0 Nantes (Daniel-Kofi Kyereh 48', Vincenzo Grifo 72')
Grup H
- Crvena Zvezda 4-1 Ferencvaros (Guelor Kanga 27'-pen, 60', Stefan Mitrovic 35', Aleksandar Katai 50'; Kristoffer Zachariassen 71')
- Monaco 3-1 Trabzonspor (Wissam Ben Yedder 14', 45+2'-pen, Axel Disasi 55'; Anastasios Bakasetas 72')