Grup A
- Ajax 0-3 Liverpool (Mohamed Salah 42', Darwin Nunez 49', Harvey Elliott 52')
- Napoli 3-0 Rangers (Giovanni Simeone 11', 16', Leo Ostigard 80')
Grup B
- Club Brugge 0-4 FC Porto (Mehdi Taremi 33', 70', Evanilson 57', Stephen Eustaquio 60')
- Atletico Madrid 2-2 Bayer Leverkusen (Yannick Carrasco 22', Rodrigo De Paul 50'; Moussa Diaby 9', Callum Hudson-Odoi 29')
Grup C
- Inter Milan 4-0 Viktoria Plzen (Henrikh Mkhitaryan 35', Edin Dzeko 42', 66', Romelu Lukaku 87')
- Barcelona 0-3 Bayern Muenchen (Sadio Mane 10', Eric Maxim Choupo-Moting 31', Benjamin Pavard 90+5')
Grup D
- Eintracht Frankfurt 2-1 Olympique Marseille (Daichi Kamada 3', Randal Kolo Muani 27'; Matteo Guendouzi 22')
- Tottenham Hotspur 1-1 Sporting CP (Rodrigo Bentancur 80'; Marcus Edwards 22')