Grup D
- Union Berlin 1-0 SC Braga (Robin Knoche 68'-pen)
- Malmo 0-2 Union SG (Teddy Teuma 10', Lazare Amani 42')
Grup E
- Omonoia Nikosia 0-2 Real Sociedad (Roberto Navarro 45+2', Brais Mendez 60')
- Manchester United 3-0 Sheriff Tiraspol (Diogo Dalot 44', Marcus Rashford 65', Cristiano Ronaldo 81')
Grup F
- Lazio 2-1 FC Midtjylland (Sergej Milinkovic-Savic 36', Pedro Rodriguez 58'; Gustav Isaksen 8')
- Sturm Graz 1-0 Feyenoord (Otar Kiteishvili 90+3')
Grup G
- Nantes 2-1 Qarabag (Ludovic Blas 17', Ignatius Ganago 90+5'; Filip Ozobic 56'-pen)
- Freiburg 1-1 Olympiakos (Lukas Kuebler 90+3'; Youssef El-Arabi 17')
Grup H
- Ferencvaros 1-1 AS Monaco (Kristoffer Zachariassen 83'; Wissam Ben Yedder 31')
- Crvena Zvezda 2-1 Trabzonspor (Aleksandar Katai 37', Aleksandar Pesic 64'; Anastasios Bakasetas 39')