Berikut mesin yang akan digunakan pebalap MotoGP pada musim 2018:
| No. | Pebalap | Tim | Mesin yang Digunakan |
| 1. | Marc Marquez | Repsol Honda | Honda versi 2018 |
| 2. | Dani Pedrosa | Honda versi 2018 | |
| 3. | Andrea Dovizioso | Ducati | Ducati vesi 2018 |
| 4. | Jorge Lorenzo | Ducati versi 2018 | |
| 5. | Valentino Rossi | Movistar Yamaha | Yamaha versi 2018 |
| 6. | Maverick Vinales | Yamaha versi 2018 | |
| 7. | Andrea Iannone | Suzuki Ecstar | Suzuki versi 2018* |
| 8. | Alex Rins | Suzuki versi 2018* | |
| 9. | Aleix Espargaro | Aprilia Gresini | Aprilia versi 2018* |
| 10. | Scott Redding | Aprilia versi 2018* | |
| 11. | Pol Espargaro | KTM | KTM versi 2018* |
| 12. | Bradley Smith | KTM versi 2018* | |
| 13. | Cal Crutchlow | LCR Honda | Honda versi 2018 |
| 14. | Takaaki Nakagami | Honda versi 2017 | |
| 15. | Johann Zarco | Yamaha Tech3 | Yamaha versi 2017 |
| 16. | Hafizh Syahrin | Yamaha versi 2017 | |
| 17. | Danilo Petrucci | Pramac Racing | Ducati versi 2018 |
| 18. | Jack Miller | Ducati versi 2017 | |
| 19. | Franco Morbidelli | Marc VDS | Honda versi 2017 |
| 20. | Thomas Luthi | Honda versi 2017 | |
| 21. | Tito Rabat | Avintia Racing | Ducati versi 2017 |
| 22. | Xavier Simeon | Ducati versi 2016 | |
| 23. | Alvaro Bautista | Angel Nieto | Ducati versi 2017 |
| 24. | Karel Abraham | Ducati versi 2016 |
*(Boleh melakukan pengembangan mesin di tengah musim)
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| Editor | : | Delia Mustikasari |
| Sumber | : | tuttomotoriweb.com |
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